Attention: Use the most suspicious nodule to guide management. Follow-up intervals may vary according to size and risk.

Attention: For part-solid nodules, measurements should be based on the solid component.

Recommendation:

No routine follow-up is needed.

Nodules <6 mm do not require routine follow-up in low-risk patients.

Recommendation:

No routine follow-up is needed.

In certain suspicious ground glass nodules smaller than 6 mm, consider follow-up at 2 and 4 years.

Recommendation:

No routine follow-up is needed.

In practice, part-solid nodules cannot be defined as such until their diameter is at least 6 mm. Nodules smaller than 6 mm do not usually require follow-up.

Recommendation:

CT at 6–12 months, then consider CT at 18–24 months

Recommendation:

CT at 6–12 months, then CT at 18–24 months

Recommendation:

CT at 3–6 months, then consider CT at 18–24 months

Recommendation:

CT at 3–6 months, then at 18–24 months

Recommendation:

Optional CT at 12 months.

Recommendation:

CT at 3-6 months, if stable consider CT and 2 and 4 years.

Multiple <6 mm pure ground-glass nodules are usually benign but consider follow-up in selected patients at high risk at 2 and 4 years.

Recommendation:

CT at 6–12 months to confirm persistence, then CT every 2 years until 5 years.

If solid component(s) or growth develops, consider resection.

Recommendation:

CT at 3–6 months to confirm persistence. If the nodule is unchanged and solid component remains,6 mm, annual CT should be performed for 5 years.

Persistent part-solid nodules with solid components smaller than 6 mm should be considered highly suspicious.

Recommendation:

CT at 3–6 months. Subsequent management based on the most suspicious nodule(s).

Recommendation:

Consider CT at 3 months, PET/CT, or tissue sampling.

Solid nodules larger than 8mm in diameter need CT, PET/CT, or tissue sampling irrespective of patient's clinical risk status.